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Anticonvulsant Use in Treating Dementia-Related Agitation

Leonard Ditmanson

Robert W Garrett

Thuy Luu

Forrest Meiling

Dementia is often accompanied by disturbances in behavior which require treatment with medications. Traditionally, antipsychotics and benzodiazepines have been used. Their modest beneficial effects must be balanced against toxicities such as drug-induced parkinsonism which leads to falls, and worsened cognitive function. Anticonvulsant medications have been used in the past to treat agitated and aggressive behaviors from various conditions. Recent reports attest to their usefulness in treating behavioral problems secondary to dementia. Carbamazepine and divalproex sodium have proven effective in treatment while newer agents like gabapentin may be useful as well. These agents may be preferable because they target a broad variety of symptoms and diseases, are less likely to induce extrapyramidal reactions and some have a low drug interaction profile.

Key Words: dementia, • agitation, • anticonvulsant, • GABA, • Alzheimer's disease, • antipsychotics.

Journal of Pharmacy Practice, Vol. 13, No. 4, 308-315 (2000)
DOI: 10.1177/089719000001300408


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