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Antidepressants: Using Pharmacology to Individualize Therapy

University of Missouri–Kansas City, M3-C19 Medical School Building, 2411 Holmes Street, Kansas City, MO 64108.dugand{at}umkc.edu

The pharmacotherapy of depression has undergone significant change in the last two decades. A new generation of antidepressant agents has displaced older drugs as first-line therapies for depression. The clinician that seeks optimal outcomes for treatment of depression must be familiar with all of the available antidepressant agents. This article will discuss the pharmacologic profile of antidepressants currently marketed in the United States, identifying similarities and differences that have clinical relevance in the management of depression. Drug selection with an emphasis on antidepressant receptor affinity will be reviewed.

Key Words: antideprsant • receptor affinity • drug selection

Journal of Pharmacy Practice, Vol. 14, No. 6, 458-466 (2001)
DOI: 10.1177/089719001129040955


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