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Journal of Pharmacy Practice
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Antidepressant Drug Interactions

Sheila R. Botts

University of Kentucky College of Pharmacy, UK Mental Health Research Center, 627 West 4th Street, Lexington, KY 40508.sbott2{at}pop.uky.edu

Cara Alfaro

National Institute of Mental Health, NIH Clinical Center, Pharmacy, Bld 10, Rm 1N-257, 10 Center Drive, Bethesda, MD 20892.calfaro{at}nih.gov

Second-generation antidepressants are more selective in their pharmacological mechanisms and offer fewer side effects and a safer toxicological profile than cyclic antidepressants and monoamine oxidase inhibitors. While the risk for pharmacodynamic interactions is more limited than with older agents with broader receptor effects, the risks for pharmacokinetic interactions is greater. The capacity of selective serotonin reuptake inhibitors to inhibit the metabolic activity of cytochrome P450 isozyme system has spurred over a decade of intense psychopharmacological and pharmacogenetics research to better the understanding of the significance of these interactions. Clinicians have had to increase their knowledge and understanding of drug interaction potential to better manage patients receiving these newer antidepressants. The following is a review of both pharmacodynamic and pharmacokinetic drug-drug interactions with antidepressants.

Key Words: drug interactions • cytochrome P-450 system • TCAs • SSRIs

Journal of Pharmacy Practice, Vol. 14, No. 6, 467-477 (2001)
DOI: 10.1177/089719001129040964
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