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Management of Acute and Chronic Sinusitis in Adult Patients

St. John's University, College of Pharmacy and Allied Health Professions, 8000 Utopia Parkway, Jamaica, NY 11439. conryj{at}stjohns.edu

Damary Castanheira, PharmD

Sinusitis is a highly prevalent illness in the United States resulting in significant sinus discomfort and pain. Diagnoses of sinusitis are typically based on patients’clinical presentations but are complicated because numerous microbiologic etiologies exist (viruses, bacteria, fungi). Along with its diagnosis, sinusitis should be classified as acute or chronic on the basis of the duration of symptoms. It is important to differentiate acute from chronic sinusitis because their etiologies and treatments may differ. Patients who present with symptoms of acute sinusitis for at least 1 week after an acute viral illness are appropriate candidates for antibiotics. Antibiotic choices should be based on local resistance patterns and patients’ characteristics, but a 2-week course of first-line antibiotics(eg, amoxicillin, trimethoprim-sulfamethoxazole) is usually sufficient. Compared to that of acute sinusitis, the management of chronic bacterial sinusitis is more complicated and controversial. Chronic sinusitis may be medically or surgically managed. Medical therapy of chronic bacterial sinusitis should consist of a prolonged course of antibiotics (4 to 6 weeks). Broad-spectrum antibiotics should be used, covering Staphylococcus aureus, •-lactamase-producing organisms, and in certain situations anaerobes. Adjunctive therapy with saline nasal spray, nasal decongestants, and inhaled nasal corticosteroids may be helpful for certain patients with acute or chronic sinusitis.

Key Words: Acute • chronic • bacteria • sinusitis • infection

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