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Journal of Pharmacy Practice, Vol. 16, No. 6, 401-413 (2003)
DOI: 10.1177/0897190003259383

New Antiproliferative Immunosuppressive Agents

Theodore M. Sievers, PharmD

Transplant Pharmacokinetic Laboratory, Dumont-UCLA Transplant Center, 10833 LeConte Avenue, Room 77-120, Los Angeles, CA 90025

Since the early 1980s, the combination of cyclosporine, azathioprine, and prednisone has been the mainstay tripledrug immunosuppressive regimen used in transplantation. However, advances in drug research, design, and development have allowed for the introduction of new agents that have greatly increased the number of immunosuppressive agents available for use in transplant recipients. Particularly, the newer antiproliferative immunosuppressive drugs (agents that directly inhibit the proliferation of T and B lymphocytes) have had an important impact on patient outcomes posttransplant. These agents are mycophenolate mofetil and sirolimus.

Key Words: Mycophenolate mofetil • sirolimus • pharmacokinetics • therapeutic drug monitoring • drug interactions


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