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The Effects of Continuous Renal Replacement on Anti-infective Therapy in the Critically Ill

New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, chk9005{at}nyp.org

Amy Dzierba, PharmD

Medical Intensive Care Unit, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York

Acute renal failure represents a frequent, severe complication in critically ill patients leading to a direct increase in mortality and resource utilization. Today, continuous renal replacement therapy (CRRT) has replaced traditional hemodialysis, providing more precise fluid and metabolic control and decreased hemodynamic instability. There are a limited number of studies conducted for the ideal dosing of individual anti-infective agents for patients receiving CRRT. However, knowledge of the basic principles of CRRT, in conjunction with pharmacokinetics and pharmacodynamics of anti-infectives, allows sound dosing recommendations to be formulated to ensure maximal killing effects with minimal risk of toxicity in patients receiving CRRT.

Key Words: Continuous renal replacement therapy • antimicrobials • renal failure • drug dosing

Journal of Pharmacy Practice, Vol. 18, No. 2, 109-117 (2005)
DOI: 10.1177/0897190004273596


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