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Journal of Pharmacy Practice
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Management of HIV Infection in Persons Co-infected With Hepatitis

Naomi S. Boston, PharmD

University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Pharmacotherapy Research Center, ACTG Pharmacology Support Laboratory, 315 Cooke Hall, Department of Pharmacy Practice, Buffalo, NY 14260, USA.

Judianne C. Slish, PharmD, BCPS

University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Pharmacotherapy Research Center, ACTG Pharmacology Support Laboratory, 315 Cooke Hall, Department of Pharmacy Practice, Buffalo, NY 14260.

Co-infection with hepatitis C virus (HCV) and/or hepatitis B virus (HBV) is becoming a rampant disparity in HIV-infected patients. The advent of antiretroviral therapy has led to agents that are effective for suppression of both HIV and HBV; however, this can not be extrapolated to patients who are coinfected with HCV. Treatment of HCV disease is often strenuous and can lead to untoward adverse effects. Co-infection with HIV often leads to higher rates of cirrhosis and liver failure in patients with HBV or HCV, compromising antiretroviral treatment in this patient population due to the hepatotoxicity of these agents. The purpose of this review is to familiarize health care providers to the management of HIV infection in patients who are also co-infected with HBV or HCV.

Key Words: HIV • hepatitis C • hepatitis B • co-infection

Journal of Pharmacy Practice, Vol. 18, No. 4, 295-309 (2005)
DOI: 10.1177/0897190005278509
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