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Journal of Pharmacy Practice, Vol. 19, No. 1, 37-52 (2006)
DOI: 10.1177/0897190005284096

Management of Hepatitis C Infection in the HIV-Infected Patient

Kelly McNelis, BS, PharmD

Christiana Care Health Services–Wilmington Hospital Annex, HIV Community Program Room 221, PO Box 1668, Wilmington, DE19899-1668; kmcnelis{at}christianacare.org

Morbidity and mortality associated with HIV infection have rapidly decreased with the introduction of highly active antiretroviral therapy. Of recent concern is the increase of unusual opportunistic infections, particularly hepatitis C virus in this population. Because of the shared route of transmission, a significant number of HIV-infected patients are also coinfected with hepatitis C virus. HIV infection has been demonstrated to increase the rate of hepatitis C virus disease progression. New data on the use of pegylated interferon plus ribavirin indicate that while cure of hepatitis C virus in the coinfected patient is a clinical challenge, it is possible. Aggressive management of anemia, drug-induced depression, and drug interactions increase the opportunity for clinical response and positive patient outcomes.

Key Words: Pegylated interferon • ribavirin • hepatitis C virus • liver biopsy • fibrosis


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