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Ibuprofen-Associated Aseptic Meningitis

Katherine P. Smith, PharmD, BCPS

University of Southern Nevada College of Pharmacy, 11 Sunset Way, Henderson, NV 89014

Aseptic meningitis is a rare condition associated with ibuprofen use. It is a diagnosis of exclusion and should be considered only after all infectious and most well-known noninfectious causes have been ruled out. The mechanism of ibuprofen-induced aseptic meningitis is not fully understood; however, most believe it is caused by a hypersensitivity-related reaction. Common symptoms of aseptic meningitis include headache, fever, nuchal rigidity, and confusion. Cerebral spinal fluid analysis generally reveals pleocytosis (the predominant white blood cell varies), with high protein concentrations and normal to low glucose concentrations. Autoimmune diseases and connective tissue diseases may predispose an individual to this condition. It is treated solely by withdrawal of the medication, although supportive treatment is often necessary. It is important that health care practitioners recognize this condition so that they are able to treat and prevent recurrence through patient education.

Key Words: ibuprofen • aseptic meningitis • Motrin • Advil

Journal of Pharmacy Practice, Vol. 19, No. 2, 113-123 (2006)
DOI: 10.1177/0897190006289981


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