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Complete Resolution of Olanzapine-Induced Diabetic Ketoacidosis

Broughton Hospital Pharmacy, 1000 South Sterling Street, Morganton, NC 28655; april.fulbright{at}ncmail.net

Keith T. Breedlove, PharmD

Broughton Hospital Pharmacy, Morganton, North Carolina

We report the case of a nondiabetic man who developed diabetic ketoacidosis associated with high-dose olanzapine. Olanzapine has been associated with diabetic ketoacidosis and also with weight gain, lipid abnormalities, and the development of type 2 diabetes. This case is of interest both because of the sudden onset and because the patient's blood glucose stabilized 1 month after discontinuation of olanzapine, thus allowing insulin therapy to be discontinued. The patient has now been stabilized on ziprasidone with no further abnormalities in blood glucose.

Key Words: Olanzapine • diabetes • diabetic ketoacidosis • ziprasidone

Journal of Pharmacy Practice, Vol. 19, No. 4, 255-258 (2006)
DOI: 10.1177/0897190006294180


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