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Journal of Pharmacy Practice, Vol. 20, No. 1, 13-28 (2007)
DOI: 10.1177/0897190007304370
© 2007 SAGE Publications

Treatment of Cognitive Decline and Psychiatric Disturbances Associated With Alzheimer's Dementia

Amie T. Blaszczyk, PharmD, CGP

Texas Tech University Health Sciences Center School of Pharmacy, Department of Pharmacy Practice, 4300 S. Lancaster Road, Building 7, R119-A, Dallas, TX 75216, amie.blaszczyk{at}ttuhsc.edu

Monica Mathys, PharmD, BCPP, CGP

Texas Tech University Health Sciences Center School of Pharmacy, Department of Pharmacy Practice, Dallas, Texas

Alzheimer's dementia (AD) is the most common type of dementia. In addition to the cognitive and functional disturbances that happen as the disease progresses, other psychological disturbances may manifest. Depression, insomnia, anxiety, and psychosis are among several psychological conditions which can occur concomitantly with AD. These changes can result in decreased quality of life for both patients and caregivers, increase caregiver burden, and impact the decision to place a patient with AD into a long-term care facility. An evidence-based review of the literature was performed to ascertain if a specific recommendation for pharmacotherapy can be made based on current research in this specific patient population.

Key Words: Alzheimer's • dementia • cognitive decline • behavioral symptoms • neuropsychiatric disturbances.


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