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Incorporating Pharmacogenomics into Practice

University of Michigan College of Pharmacy, Department of Clinical Sciences and School of Medicine, vellingr{at}umich.edu, Department of Psychiatry

Jessica Moline, BS

University of Michigan genetic counseling program

The goal for this issue of the Journal of Pharmacy Practice is to provide an overview of pharmacogenomics and highlight research done in select therapeutic areas such as oncology, psychiatry, cardiology, and HIV, although pharmacogenomics is taking center stage in other therapeutic areas as well. At the root of all pharmacogenomic investigations is pharmacy, which is why it is so important for pharmacists to gain an understanding of this field and clinical applications of this science, particularly as it relates to their practice and their patients. Pharmacists are experts in pharmacokinetics and pharmacodynamics, and they therefore represent ideal health care professionals for incorporating pharmacogenomics into therapeutic drug monitoring. We are currently in a critical period of time in which pharmacists need to become engaged in the decision-making process regarding how best to implement pharmacogenomics into clinical practice. As part of this chapter, we will outline the role of the Human Genome Project and the Food and Drug Administration, both of which are instrumental to the advancement of pharmacogenomics. Lastly, we will be summarizing some of the barriers we still face regarding clinical applicability of this science and the potential role of genetic counselors in the incorporation of this science into clinical practice.

Key Words: Human genome • pharmacogenomics • genetic testing • genetic counseling.

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