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Probable Labetalol-Induced Hepatotoxicity

Regina Ginzburg, PharmD

St. John's University College of Pharmacy & Allied Health Professions, Ambulatory Pharmacy Faculty, Beth Israel Residency in Urban Family Practice-Institute for Urban Family Health, 8000 Utopia Parkway, St. Albert's Hall Room 114, Queens, NY 11439, ginzburr{at}stjohns.edu

Resa Singleton, MD

Beth Israel Residency in Urban Family Practice-Institute for Urban Family Health, New York, New York

Wendy B. Barr, MD, MPH, MSCE

Beth Israel Residency in Urban Family Practice-Institute for Family Health, Jamaica, New York, New York

This article reports a case of probable hepatotoxicity induced by therapeutic doses of labetalol. A 34-year-old postpartum woman was started on labetalol during a preeclamptic episode in the hospital. During the patient's 4-week postpartum office visit, she reported having dark urine for the previous 2 weeks. A liver function test showed substantial enzyme elevation, which improved after discontinuation of labetalol therapy. Labetalol-induced hepatotoxicity, although uncommon, can occur. Published data report this occurrence only in middle-aged or older patients. This appears to be the first case report of postpartum labetalol-induced hepatotoxicity. Hepatotoxicity may occur as a result of labetalol therapy. More judicious monitoring in patients on labetalol therapy may be warranted to prevent serious outcomes.

Key Words: Labetalol • hepatotoxicity • postpartum.

Journal of Pharmacy Practice, Vol. 20, No. 3, 283-287 (2007)
DOI: 10.1177/0897190007306173
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