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Journal of Pharmacy Practice
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Sulfonamide Allergy and Possible Cross-Reactivity

Helen Kourlas, BS, PharmD

A&M Schwartz College of Pharmacy & Health Sciences at Long Island University, Brooklyn, VA New York Harbor Healthcare, Pharmacy Department, New York, New York

Susan Morey, PharmD

VA New York Harbor Healthcare, smmorey2{at}gmail.com

True allergic reactions are IgE-mediated immune reactions and are also termed type I reactions, where the spectrum of presentation may range from urticaria to severe anaphylactic shock. Currently, 3% of the patients who use sulfonamide antibiotics develop an allergic reaction, with the most common being the development of a maculopapular rash. Sulfonamides are chemical compounds that can be further divided into 3 groups based on differences in their structural makeup. Several cases reviewing the cross-reactivity between sulfonamide antibiotics and nonantibiotics have suggested an increased risk of cross-reactivity and therefore recommend other treatment strategies to avoid a possible anaphylactic reaction; however, other reports argue that patients with a history of sulfonamide allergy who received sulfonamide nonantibiotics did not experience any adverse reactions. Pertinent data extracted from these studies are reviewed and evaluated.

Key Words: Sulfonamides • hypersensitivity • antibacterial agents • cross-reaction.

Journal of Pharmacy Practice, Vol. 20, No. 5, 399-402 (2007)
DOI: 10.1177/0897190007305686
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