This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pai, A. B. Articles by Conner, T. A. Search for Related Content Social Bookmarking                         What's this?

Oxidative Stress and Inflammation in Chronic Kidney Disease: Role of Intravenous Iron and Vitamin D

University of New Mexico Health Sciences Center, College of Pharmacy and School of Medicine, Albuquerque, New Mexico, abpai{at}salud.unm.edu

Todd A. Conner, PharmD

University of New Mexico Health Sciences Center, College of Pharmacy and School of Medicine, Albuquerque, New Mexico

Cardiovascular disease (CVD) is the leading cause of death among chronic kidney disease patients (CKD). The etiology of CVD in CKD is multifactorial and increasing evidence points to the important contribution of "nontraditional" risk factors including oxidative stress and inflammation. CKD is associated with a chronic imbalance of prooxidant and antioxidant factors that results in a state of chronic inflammation. Intravenous iron supplementation has been shown to induce oxidative stress and has been associated with lipid peroxidation and DNA damage. Conversely, treatment with vitamin D analogs has been associated with improved mortality in hemodialysis patients in 2 recent large cohort studies. These data suggest that vitamin D analogs may exert effects beyond their pharmacologic role in parathyroid hormone suppression. This article addresses the current data regarding the relative contributions of intravenous iron supplementation and vitamin D analog therapy on oxidative stress and inflammation in CKD patients.

Key Words: chronic kidney disease • oxidative stress • inflammation • intravenous iron • vitamin D

Journal of Pharmacy Practice, Vol. 21, No. 3, 214-224 (2008)
DOI: 10.1177/0897190008316288


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?