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Journal of Pharmacy Practice
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Macrovascular Complications of Diabetes Mellitus

Donald S. Nuzum, PharmD

Wingate University School of Pharmacy, Wingate, North Carolina, dnuzum{at}wingate.edu

Tonja Merz, PharmD

Wingate University School of Pharmacy, Wingate, North Carolina

Adults with diabetes mellitus frequently develop macrovascular complications. Vascular disease is a frequent cause of morbidity and mortality among patients with diabetes. Diabetes and vascular diseases remain among the most common causes of death in the United States. A number of clinical trials and practice guidelines have been published addressing the management of macrovascular complications. The cornerstone of preventing or delaying the progression of macrovascular complications of diabetes is aggressive management of hypertension and cholesterol. Angiotensin-converting enzyme inhibitors have proven effective in managing hypertension and avoiding other complications of diabetes. The body of evidence for angiotensin receptor blockers is growing in this area as well. Statins have been repeatedly proven to be the first-line agents in the management of dyslipidemia. Lifestyle modification strategies and antiplatelet therapy also remain essential. This review will focus on the role of newer diagnostic techniques, clinical trial evidence, and appropriate pharmacotherapy for macrovascular complications of diabetes.

Key Words: Diabetes • hypertension • dyslipidemia • macrovascular complications

This version was published on April 1, 2009

Journal of Pharmacy Practice, Vol. 22, No. 2, 135-148 (2009)
DOI: 10.1177/0897190008326444
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