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Management of Cirrhosis and Associated ComplicationsUniversity of Colorado Denver, School of Pharmacy, Aurora, Colorado, rob.maclaren{at}ucdenver.edu Liver cirrhosis is the encapsulation or replacement of injured tissue by collagen, resulting in end-stage liver disease and portal hypertension. The consequences of cirrhosis are impaired hepatocyte function, increase intrahepatic circulatory resistance, portal hypertension, and the development of hepatocellular carcinoma. Complications include encephalopathy, coagulopathy, varices, ascites, spontaneous bacterial peritonitis, epatorenal syndrome, and hepatopulmonary syndrome. Managing patients with acute or chronic liver failure is challenging, and liver failure may have profound effects on other organ systems. Most therapies are directed at managing the complications and bridging patients to liver transplantation. The clinician must be aware of the pathologic presentations and the appropriate management, including pharmacologic and nonpharmacologic therapies, goals and end points of therapy, and monitoring of therapy. This review focuses on the management of the complications directly associated with liver dysfunction (encephalopathy and coagulopathy) and portal hypertension (varices, ascites, spontaneous bacterial peritonitis, hepatorenal syndrome, hepatopulmonary syndrome).
Key Words: liver • cirrhosis • portal hypertension • encephalopathy • coagulopathy • varices • ascites • spontaneous bacterial peritonitis • hepatorenal syndrome • hepatopulmonary syndrome
This version was published on June
1, 2009 Journal of Pharmacy Practice, Vol. 22, No. 3,
290-309 (2009) |
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