| Sign In to gain access to subscriptions and/or personal tools. |
Novel Approaches to the Treatment of Type 2 DiabetesDepartment of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, Florida, stonge{at}cop.ufl.edu
Family Health Center East, Orlando, Florida
Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, Florida The emergence of the glucoregulatory hormone, glucagon-like peptide-1, has expanded our understanding of glucose homeostasis. The glucoregulatory actions of glucagon-like peptide-1 include enhancement of glucose-dependent insulin secretion, suppression of inappropriately elevated glucagon secretion, slowing of gastric emptying, and reduction of food intake. Two approaches have been developed to potentiate the effects of glucagon-like peptide-1 in those with type 2 diabetes. The glucagon-like peptide-1 analogs, such as exenatide, and dipeptidyl peptidase-IV inhibitors, such as sitagliptin, are currently available whereas others are in the final stages of development. These agents effectively reduce hemoglobin A1c while providing the other benefits associated with increased glucagon-like peptide-1. They also offer the potential to preserve the β-cell function. The effects on cardiovascular disease, if any, are unknown. Based on the current evidence, these agents represent viable second-and third-line options in the management of type 2 diabetes.
Key Words: incretin • type 2 diabetes • GLP-1 • DPP-IV inhibitor
This version was published on June
1, 2009 Journal of Pharmacy Practice, Vol. 22, No. 3,
320-332 (2009) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
|
|
 |
Sign In to gain access to subscriptions and/or personal tools.
