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Journal of Pharmacy Practice
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Drug Treatment of Depression

Candace S. Brown

Department of Clinical Pharmacy, University of Tennessee, 26 S Dunlap, Rm 210B, Memphis, TN 38163

Stephen G. Bryant

From the Department of Clinical Pharmacy, University of Tennessee, Memphis, TN, Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch at Galveston, Galveston, TX, University of Texas College of Pharmacy at Austin, Austin, TX.

The major advantage of the new generation of antidepressants lies in their enhanced ability to avoid unwanted side effects, such as anticholinergic or cardiovascular toxicities, and in many cases, to reduce fatalities after overdose. Second-generation antidepressants are as effective as the first generation agents, but are more selective, enabling precise targeting of symptoms. Caution in recommending the newer antidepressants must be applied, however, because these agents possess differing side effects, and unforeseen toxicities may not appear until after several years of use. Conventional tricyclics should not be overlooked in managing the depressed patient. This article discusses the symptoms of major depression, followed by the latest information on second-generation antidepressants. It concludes by providing the pharmacist with guidelines for when to select a newer over an older agent.

Journal of Pharmacy Practice, Vol. 3, No. 4, 252-261 (1990)
DOI: 10.1177/089719009000300407
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