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Journal of Pharmacy Practice
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The Safety and Effectiveness of Dexmedetomidine When Used for More Than 24 Hours in an Adult Intensive Care Setting

Matthew Klimek

St John's University, Queens, New York

Matthew M. Lacroix, PharmD

St John's University College of Pharmacy and Health Professions, Department of Clinical Pharmacy Practice, Queens, New York, Clinical Pharmacist Preceptor, North Shore University Hospital, Manhasset, New York, lacroixm{at}stjohns.edu

Dexmedetomidine is a new analgesic and anxiolytic used in the intensive care setting. It has been indicated for use for less than 24 hours to aid in intubation or extubation of a patient. The advantages for dexmedetomidine compared with propofol or benzodiazepines are that it has fewer sedating effects and a short half-life. Several retrospective studies and case reports have reported its use longer than the indicated 24 hours. They reported that dexmedetomidine is safe to use past the 24-hour indicated time of use, with the same or fewer adverse side effects reported.

Key Words: Dexmedetomidine • hypnotics and sedatives • non-narcotic analgesics • intensive care units • time factors • adult • humans.

References

Bhana N., Goa KL, McClellan KJ Dexmedetomidine. Drugs. 2000;59:263-268.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Shehabi Y., Ruettimann U., Adamson H., Innes R., Ickeringill M. Dexmedetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects. Intensive Care Med. 2004;30:2188-2196.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Precedex (dexmedetomidine HCl) Injection [package insert]. Lakeville, IL: Hospira Inc; April 2004.

Martin E., Ramsay G., Mantz J., Sum-Ping ST The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med. 2003;18:29-41.[Abstract/Free Full Text]

Venn RM, Hell J., Grounds RM Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care. 2000;4:302-308.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Micromedex® Healthcare Series [Internet database]. Greenwood Village, CO: Thomson Micromedex [updated periodically].

Dasta JF, Kane-Gill SL, Durtschi AJ. Comparing dexmedetomidine prescribing patterns and safety in the naturalistic setting versus published data. Ann Pharmacother. 2004;38: 1130-1135.[Abstract/Free Full Text]

MacLaren R., Forest LK, Kiser TH Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and hemodynamic parameters. Pharmacotherapy. 2007;27:351-359.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Talke P., Li J., Jain U., et al. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. Anesthesiology. 1995;82:620-633.[Web of Science][Medline] [Order article via Infotrieve]

Riker RR, Ramsay MAE, Prielipp RC, Jorden V. Long-term dexmedetomidine infusions for ICU sedation: a pilot study [abstract]. Anesthesiology. 2001;95:A383.

Multz A. Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal. Anesth Analg. 2003;96:1054-1055.[Abstract/Free Full Text]

Dasta JF, Jacobi J., Sesti AM, McLaughlin TP Addition of dexmedetomidine to standard sedation regimens after cardiac surgery: an outcomes analysis. Pharmacotherapy. 2006;26: 798-805.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Journal of Pharmacy Practice, Vol. 20, No. 6, 474-477 (2007)
DOI: 10.1177/0897190007311672
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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Klimek, M.
Right arrow Articles by Lacroix, M. M.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
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