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The Utility of Fluoroquinolones in the Critically Ill
Clinical Assistant Professor, UAB-Huntsville Medical Campus
* To whom correspondence should be addressed. E-mail: wargoka{at}auburn.edu.
Fluoroquinolone antibiotics have been used for more than 40 years to treat a variety of infections from simple uncomplicated urinary tract infections to infections as severe as nosocomial-acquired pneumonia. Their availability both orally and intravenously, ease of dosing, favorable safety profile, and broad spectrum of activity have led to the pervasive use of these agents in both the community and institutions. Unfortunately, this widespread use has led to the development of resistance and subsequently, increased mortality. Resistance, specifically with Pseudomonas aeruginosa and Escherichia coli, as well as their association with the development of Clostridium difficile–associated diarrhea, has led many clinicians to question the use of fluoroquinolones in the critically ill. This article will review these issues related to the use of fluoroquinolones, in an effort to better define their role among institutionalized patients.
First published on July 8, 2008, doi:10.1177/0897190008318502 |
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